Annie O'Donnell started her acting career landing roles in such films as the Richard Benjamin comedy "Saturday the 14th" (1981), the Clint Eastwood action flick "Heartbreak Ridge" (1986) and the Diane Keaton dramedy "Baby Boom" (1987). She also appeared in the action movie "Easy Wheels" (1989) with Paul Le Mat, the comedy "Homer and Eddie" (1989) with James Belushi and the action film "Kickboxer 2" (1991) with Sasha Mitchell. She continued to work steadily in film throughout the nineties, appearing in the comedy "Black Sheep" (1996) with Chris Farley, "Born Bad" (1998) and the dramatic comedy "The Players Club" (1998) with Ice Cube. She also appeared in "Blast From the Past" (1999) with Brendan Fraser.

More recently, she continued to act in "King of California" (2007) with Michael Douglas, the Shia LaBeouf hit action picture "Transformers: Dark of the Moon" (2011) and the Jean Dujardin comedic drama "The Artist" (2011). She also worked in television during these years, including a part on "Grey's Anatomy" (ABC, 2004-). She also lent her distinctive voice to "Diary of a Wimpy Kid: Rodrick Rules" (2011). O'Donnell most recently acted in the Zoe Kazan comedy "The Pretty One" (2014).