Calderon earned her BA from the University in San Antonio and studied acting at the American Academy of Dramatic Arts and under coaches Ivana Chubbuck, Larry Moss, and Jennifer Rincon. She performed in stage plays such as "MacBeth", "Blade to the Heat", "Lysistrata", and on the CBS "Diversity Showcase". She appeared in the fantasy comedy Being John Malkovich (1999, with Willie Garson, Richard Fancy, Patti Tippo, Andy Dick, and Winona Ryder), the short films The King (2002, with Jenna Z. Wilson) and Long Story Short (2004), the comedy Breaking the Fifth (2004, with Frank Langella), the comedy Outta Sync (2006, with Mark Chaet and Cecelia Specht), and in the drama The God Project (2008, with Troy Brenna and Damon Williams).

Guest roles include Whoopi Goldberg’s Strong Medicine (2003, starring Jenifer Lewis, with Michelle Horn), The Shield (2004, with Michael Jace, Jay Karnes, Benito Martinez, and Rif Hutton), Criminal Minds (2007, with Billy Brown and Kenneth Meseroll), and Heroes (2009, with Cristine Rose and Jon Donahue).